Includes actinium-based clinical-stage radioconjugate targeting PSMA for prostate
cancer, 管道 of radioconjugates and state-of-the-art R&D和制造
设施
澳门在线赌城娱乐已经签署了收购融合制药公司的最终协议.该公司是一家临床阶段的澳门第一赌城在线娱乐公司，正在开发下一代放射性缀合物(rc)。. The acquisition marks a major step forward in 澳门在线赌城娱乐 delivering on its ambition to transform cancer treatment and outcomes for patients by replacing traditional regimens like chemotherapy and radiotherapy with more targeted treatments.
RCs have emerged as a promising modality in cancer treatment over recent years. These medicines deliver a radioactive isotope directly to cancer cells through precise targeting using molecules such as antibodies, 多肽或小分子. This approach has many potential advantages compared to traditional radiotherapy including minimising damage to healthy cells and enabling access to tumours not reachable through external beam radiation.
此次收购补充了澳门在线赌城娱乐领先的肿瘤产品组合，增加了融合产品线, including their most advanced programme, fpi - 2265, 转移性去势抵抗性前列腺癌(mCRPC)的潜在新疗法. fpi - 2265 targets prostate-specific membrane antigen (PSMA), a protein that is highly expressed in mCRPC, and is currently in a Phase II trial.
The acquisition brings new expertise and pioneering R&D，制造和供应链能力的锕系rc到澳门在线赌城娱乐. It also strengthens the Company’s presence in and commitment to Canada.
Susan Galbraith, Executive Vice President, 肿瘤学 R&D, 澳门在线赌城娱乐, 他说:“如今，30%到50%的癌症患者在治疗过程中的某个阶段接受了放疗, 收购融合将进一步增强澳门第一赌城在线娱乐的雄心，用下一代放射性缀合物改变这方面的护理. 与聚变一起, 澳门第一赌城在线娱乐有机会加速fpi - 2265作为一种潜在的前列腺癌新疗法的开发, 并利用其创新的锕基平台开发放射性缀合物作为基础方案.”
约翰强悍, 首席执行官, 融合, 他说:“此次收购结合了融合在无线电共轭物方面的专业知识和能力, including our industry-leading radiopharmaceutical R&D, 管道, manufacturing and actinium-225 supply chain, 利用澳门在线赌城娱乐在小分子和生物制品工程领域的领先地位，开发新型放射性缀合物. 扩大澳门第一赌城在线娱乐与澳门在线赌城娱乐的现有合作，澳门第一赌城在线娱乐已经开发了FPI-2068, an EGFR-cMET targeted radioconjugate into Phase I clinical trials, gives us a unique opportunity to accelerate the 发展 of next-generation radioconjugates with the aim of transforming patient outcomes.”
融合 will become a wholly owned subsidiary of 澳门在线赌城娱乐, with operations continuing in Canada and the US.
金融方面的考虑
Under the terms of the definitive agreement, 澳门在线赌城娱乐, 通过子公司, 将根据一项安排计划，以21美元的价格收购融合的所有流通股.在交易结束时每股00美元现金加上3美元的不可转让或有价值权.在达到指定的监管里程碑后，可支付每股00美元的现金. 对价的预付现金部分代表约20亿美元的交易价值, a 97% premium to 融合’s closing market price of $10.64 on 18th 较30天成交量加权平均价格(VWAP) 11美元溢价85%.在此公告之前37. 结合, the upfront and maximum potential contingent value payments represent, 如果实现, a transaction value of approximately $2.4bn, a 126% premium to 融合’s closing market price on 18th March 2024 and a 111% premium to the 30-day VWAP. 作为交易的一部分, 澳门在线赌城娱乐 will acquire the cash, cash equivalents and short term investments on 融合’s balance sheet, 截至31年，总计2.34亿美元st 2023年12月.
The transaction is expected to close in the 证券交易委员会ond quarter of 2024, subject to customary closing conditions, including the approval of 融合 shareholders and regulatory clearances.
笔记
肿瘤学中的放射缀合物
RCs combine the precise targeting of antibodies, 具有强效医用放射性同位素的小分子或多肽，可直接向癌细胞传递辐射. 通过寻找癌细胞, 与传统放射治疗相比，RCs提供了更精确的癌细胞杀伤机制, with the goal of improving efficacy while minimising toxicity on healthy cells. RCs are administered via systemic delivery, which enables their use in tumour types not accessible to external beam radiation and the targeting of cancer cells that have spread from the main tumour to other sites in the body.
fpi - 2265
fpi - 2265是一种基于锕-225的psma靶向mCRPC的RC，目前处于II期试验中.
锕-225能释放α粒子，有望成为治疗癌症的下一代放射性同位素. By delivering a greater radiation dose over a shorter distance, 像锕-225这样的α粒子有可能更有效地杀死癌细胞, 有针对性的交付, t在这里by minimising damage to surrounding healthy tissue.
关于融合
融合 Pharmaceuticals是一家临床阶段肿瘤公司，专注于开发下一代rc. 融合 connects alpha particle emitting isotopes to various targeting molecules to selectively deliver the alpha emitting payloads to tumours. 融合’s clinical-stage 发展 portfolio includes lead programme, fpi - 2265, targeting PSMA for mCRPC and novel RCs targeting solid tumours.
澳门在线赌城娱乐在 肿瘤学
澳门在线赌城娱乐正在引领肿瘤学领域的一场革命，致力于为各种形式的癌症提供治疗, following the science to understand cancer and all its complexities to discover, develop and deliver life-changing medicines to patients.
The Company's focus is on some of the most challenging cancers. It is through persistent innovation that 澳门在线赌城娱乐 has built one of the most diverse portfolios and 管道s in the industry, 有可能催化医学实践的变化，改变病人的体验.
澳门在线赌城娱乐 has the vision to redefine cancer care and, 有一天,, eliminate cancer as a cause of death.
Additional information and w在这里 to find it
In connection with the proposed transaction, 融合打算向美国证券交易委员会(SEC)提交代理通函。. INVESTORS AND SECURITY HOLDERS ARE URGED TO READ THE PROXY CIRCULAR IN ITS ENTIRETY IF AND WHEN IT BECOMES AVAILABLE AND ANY OTHER DOCUMENTS FILED WITH THE SEC IN CONNECTION WITH THE PROPOSED TRANSACTION OR INCORPORATED BY REFERENCE IN THE PROXY CIRCULAR BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION ABOUT THE PROPOSED TRANSACTION AND RELATED MATTERS.
投资者和证券持有人将能够免费获得委托书和其他相关文件的副本, when such documents are filed with the SEC, 在美国证券交易委员会的网站www上.证券交易委员会.政府. Copies of the documents filed with the SEC by 澳门在线赌城娱乐 may be obtained at no charge on the investor relations page of 澳门在线赌城娱乐’s internet website at www.澳门在线赌城娱乐.com/investor-relations.html. 融合向SEC提交的文件副本可根据“投资者”免费获得 & 媒体” 证券交易委员会tion of 融合’s website at http://ir.fusionpharma.com/sec-filings.
Participants in the solicitation
This communication does not constitute an offer to buy or sell or the solicitation of an offer to buy or sell any 证券交易委员会urities or a solicitation of any vote or approval. This communication is not a substitute for any circular 融合 may file with the SEC in connection with the proposed transaction.
澳门在线赌城娱乐, its directors and certain of its executive officers and other employees may, 根据证券交易委员会的规定, 被视为与拟议交易有关的代理人征集的参与者. Information regarding such persons, including a description of their respective direct or indirect interests, by 证券交易委员会urity holdings or otherwise, will be included in the proxy statement when it is filed with the SEC. Information about 澳门在线赌城娱乐’s directors and executive officers is also available in 澳门在线赌城娱乐’s Form 20-F filed with the SEC on 20th 以及澳门在线赌城娱乐随后向美国证券交易委员会提交的其他文件. 这些文件将从上述来源免费提供.
融合, its directors and certain of its executive officers and other employees may, 根据证券交易委员会的规定, 被视为与拟议交易有关的代理人征集的参与者. Information regarding such persons, including a description of their respective direct or indirect interests, by 证券交易委员会urity holdings or otherwise, will be included in the proxy statement when it is filed with the SEC. 有关融合董事和高管的信息也可在融合于16日向美国证券交易委员会提交的10-K表格中获得th 2023年3月, 融合’s proxy statement for its annual meeting of shareholders, which was filed with the SEC on 27th April 2023, and other documents subsequently filed by 融合 with the SEC. 这些文件将从上述来源免费提供.
前瞻性陈述
This document may include statements that are not statements of historical fact, 或"前瞻性陈述",” including with respect to the proposed acquisition of 融合 by 澳门在线赌城娱乐. Such forward looking statements include, 但不限于, 澳门在线赌城娱乐和融合完成安排协议所设想的交易的能力, 包括双方满足安排协议中规定的条件的能力, statements about the expected timetable for completing the transaction, 澳门在线赌城娱乐’s and 融合’s beliefs and expectations and statements about the benefits sought to be achieved in 澳门在线赌城娱乐’s proposed acquisition of 融合, the potential effects of the acquisition on both 澳门在线赌城娱乐 and 融合, the possibility of any termination of the arrangement agreement, as well as the expected benefits and success of FPI 2265, and other 管道 product or any combination product. These statements are based upon the current beliefs and expectations of 澳门在线赌城娱乐’s and 融合’s management and are subject to significant risks and uncertainties. T在这里 can be no guarantees that the conditions to the closing of the proposed transaction will be satisfied on the expected timetable or at all or that fpi - 2265 will receive the necessary regulatory approvals or prove to be commercially successful if approved. If underlying assumptions prove inaccurate or risks or uncertainties materialise, 实际结果可能与前瞻性陈述中所述的结果有重大差异.
Risks and uncertainties include, 但不限于, uncertainties as to the timing of the proposed transaction; uncertainties as to how many of 融合’s shareholders will vote in favour of the proposed transaction; the possibility that various conditions to the consummation of the proposed transaction may not be satisfied or waived; the ability to obtain necessary regulatory approvals or to obtain them on acceptable terms or within expected timing; the effects of disruption from the transactions contemplated by the arrangement agreement and the impact of the announcement and pendency of the transactions on 融合’s business; the risk that shareholder litigation in connection with the proposed transaction may result in significant costs of defence, indemnification and liability; the possibility that the achievement of the specified milestone described in the contingent value rights agreement may take longer to achieve than expected or may never be achieved and the resulting contingent milestone payment may never be realised; general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of COVID 19; the impact of pharmaceutical industry regulation and health care legislation in the United States and internationally; competition from other products; and challenges in在这里nt in new product 发展, including obtaining regulatory approval.
澳门在线赌城娱乐和融合均不承担公开更新任何前瞻性声明的义务, whether as a result of new information, 未来事件或其他, except to the extent required by law. Additional factors that could cause results to differ materially from those described in the forward-looking statements can be found in 澳门在线赌城娱乐’s Annual Report on Form 20 F for the year ended 31st 2023年12月 and 融合’s Annual Report on Form 10 K for the year ended 31st 在每个案例中，经随后向SEC提交的任何文件修订. 澳门在线赌城娱乐和融合向美国证券交易委员会提交的这些文件和其他文件可在www上查阅.证券交易委员会.政府.
澳门在线赌城娱乐 (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, 发展, and commercialisation of prescription medicines in 肿瘤学, 罕见疾病, 和澳门第一赌城在线娱乐, 包括心血管, 肾 & 代谢、呼吸 & 免疫学和疫苗 & 免疫疗法. 总部设在剑桥, UK, 澳门在线赌城娱乐在100多个国家开展业务，其创新药物被全球数百万患者使用. 请访问 澳门在线赌城娱乐.com and follow the Company on social media @澳门在线赌城娱乐
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艾德里安·坎普
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